Fields et al. demonstrate the viability of targeting a shared cytokine receptor for comprehensive signaling blockade of all associated cytokines. CAN10 and 3G5, two anti-IL-1RAcP antibodies, target distinct epitopes on this shared receptor and potently block IL-1α, IL-1β, IL-33, IL-36α, IL-36β, and IL-36γ signaling.
Related Posts
Genomic deletions explain the generation of alternative BRAF isoforms conferring resistance to MAPK inhibitors in melanoma
Aya et al. show that the production of alternative BRAF mRNA isoforms (altBRAFs), associated with resistance to BRAF inhibitors in melanoma, is caused by genomic deletions rather than by alternative splicing, as previously thought. They also find that altBRAFs are present […]
LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion
Terao et al. demonstrated how dysregulated cholesterol metabolism drives macrophage senescence and the development of subretinal drusenoid deposits in mice. LXR/CD38 signaling activated by cholesterol reduces NAD+ availability and promotes macrophage senescence. Senolytic agents targeting NAD+ decline and senescent macrophages are […]
A fitness landscape instability governs the morphological diversity of tip-growing cells
Ohairwe et al. demonstrate that an intrinsic mechanical instability in the convergent mechanism of “inflationary” cell growth shared by diverse tip-growing cells leads to a bifurcation (branching) of their fitness landscape. This bifurcation strictly constrains natural tip-growing cell shapes.