| TNF-α (TNFSF2) | Macrophages, NK, T, and B cells | TNFR1/2 (TNFRSF1A, DR1) | Hematopoietic and immune cells |
| | (TNFRSF1B) | Immune and endothelial cells |
| LT-α (TNFSF1) | NK, T, and B cells | TNFR1 | Hematopoietic and immune cells |
| | TNFR2 | |
| LT-β (TNFSF3) | Activated CD4+ T cells and T, DC, and NK cells | LT-βR (TNFRSF3) | NK cells, CD4+ and CD8+ T cells |
| OX40L (TNFSF4), CD252, gp34 | B and T cells, DCs, endothelial and smooth muscle cells | OX40 (TNFRSF4), CD134 | Activated CD4+ T cells and neutrophils |
| CD40L (TNFSF5), CD154, gp39 | Activated CD4+ T cells, NK, mast cells, basophils and eosinophils | CD40 (TNFRSF5), p50 | B cells, monocytes, DCs, thymic epithelium |
| FasL (TNFSF6), CD95L, Apo1L | Activated splenocytes, thymocytes, nonlymphoid tissues, NK cells | Fas (TNFRSF6), CD95, Apo1, DR2 | Epithelial cells, hepatocytes, activated mature lymphocytes, and transformed cells |
| | DcR3 (TNFRSF6B) | Lung and colon cells |
| CD27L (TNFSF7), CD70 | NK, T, B, and mast cells, smooth muscle and thymic epithelial cells | CD27 (TNFRSF7) | Hematopoietic progenitors, CD4+ and CD8+ T cells |
| CD30L (TNFSF8), CD153 | Activated T and B cells, monocytes, granulocytes, thymic epithelial cells | CD30 (TNFRSF8) | T and B cells, NK cells, macrophages, eosinophils |
| 4–1BBL (TNFSF9) | APCs (DCs, macrophages and B cells), mast cells | 4–1BB (TNFRSF9), CD137, ILA | T, NK and mast cells, neutrophils |
| TRAIL (TNFSF10), Apo2L | NK and T cells, DCs | TRAILR1 (TNFRSF10A), DR4, Apo2 | Most normal and transformed cells |
| | TRAILR2 (TNFRSF10B), DR5 | |
| | TRAILR3 (TNFRSF10C), DcR1 | |
| | TRAILR4 (TNFRSF10D), DcR2 | |
| RANKL (TNFSF11), TRANCE, OPGL, ODF | T cells, thymus, lymph nodes | RANK (TNFRSF11A), TRANCER | Osteoclasts, osteoblasts, and activated T cells |
| | OPG (TNFRSF11B), OCIF | Bone marrow stromal cells, B cells, DCs |
| TWEAK (TNFSF12), Apo3L | Monocytes, macrophages, DCs, NK cells | Fn14 (TNFRSF12A), TWEAKR | Endothelial cells and fibroblasts, tissue progenitor cells |
| T and B cells | | |
| APRIL (TNFSF13), TALL-2, TRDL-1 | Macrophages, lymphoid cells and tumor cells | BCMA (TNFRSF13A/17) | B cells, PBLs, spleen, thymus, lymph nodes, liver, adrenals |
| | TACI (TNFRSF13B) | B cells, activated T cells, PBLs, spleen, thymus, small intestine |
| BAFF (TNFSF13B), BLYS, THANK | T cells, monocytes, macrophages, DCs | TACI (TNFRSF13B) | B cells, resting T cells, PBLs, spleen, lymph nodes |
| | BAFFR (TNFRSF13C) | |
| | BCMA (TNFRSF17) | |
| LIGHT (TNFSF14), HVEML, LT-γ | T cells, granulocytes, monocytes, DCs | LIGHTR (TNFRSF14), HVEM | T and B cells, monocytes, and lymphoid cells |
| | LT-βR | Nonlymphoid hematopoietic and stromal cells |
| TL1A (TNFSF15), VEGI | Endothelial cells | DR3 (TNFRSF25) | NK cells, CD4+ and CD8+ cells |
| APCs | DcR3 | Activated T cells |
| GITRL (TNFSF18) | HUVECs | GITR (TNFRSF18), AITR | CD4+ CD25+ T cells |
| EDA-A1 | Skin | EDAR | Ectodermal derivative |
| EDA-A2 | Skin | XEDAR (TNFRSF27) | Ectodermal derivative, embryonic hair follicles |
| NI | | TROY (TNFRSF19), TAJ | Embryo skin, epithelium, hair follicles, brain |
| NI | | RELT (TNFRSF19L) | Lymphoid and hematopoietic tissues |
| Amyloid polypeptide (APP) (not a TNFSF member) | | DR6 (TNFRSF21) | Differentiating neurons, T cells |
| NI | | NGFR (TNFRSF16), CD271 | Neuronal axons, Schwann cells, perineural cells |