https://www.newtheoryofcancer.com Recent & Emerging Research Elucidations Mon, 22 Apr 2024 21:54:39 +0000 en-US hourly 1 https://wordpress.org/?v=6.6.2 https://www.newtheoryofcancer.com/2024/04/22/tnf-superfamily-table/ Mon, 22 Apr 2024 21:54:38 +0000 https://www.newtheoryofcancer.com/?p=177 TNF family

Ligand Name (Symbol), Alternative Names	Expression	Receptor Name (Symbol), Alternative Names	Expression
TNF-α (TNFSF2)	Macrophages, NK, T, and B cells	TNFR1/2 (TNFRSF1A, DR1)	Hematopoietic and immune cells
		(TNFRSF1B)	Immune and endothelial cells
LT-α (TNFSF1)	NK, T, and B cells	TNFR1	Hematopoietic and immune cells
		TNFR2
LT-β (TNFSF3)	Activated CD4+ T cells and T, DC, and NK cells	LT-βR (TNFRSF3)	NK cells, CD4+ and CD8+ T cells
OX40L (TNFSF4), CD252, gp34	B and T cells, DCs, endothelial and smooth muscle cells	OX40 (TNFRSF4), CD134	Activated CD4+ T cells and neutrophils
CD40L (TNFSF5), CD154, gp39	Activated CD4+ T cells, NK, mast cells, basophils and eosinophils	CD40 (TNFRSF5), p50	B cells, monocytes, DCs, thymic epithelium
FasL (TNFSF6), CD95L, Apo1L	Activated splenocytes, thymocytes, nonlymphoid tissues, NK cells	Fas (TNFRSF6), CD95, Apo1, DR2	Epithelial cells, hepatocytes, activated mature lymphocytes, and transformed cells
		DcR3 (TNFRSF6B)	Lung and colon cells
CD27L (TNFSF7), CD70	NK, T, B, and mast cells, smooth muscle and thymic epithelial cells	CD27 (TNFRSF7)	Hematopoietic progenitors, CD4+ and CD8+ T cells
CD30L (TNFSF8), CD153	Activated T and B cells, monocytes, granulocytes, thymic epithelial cells	CD30 (TNFRSF8)	T and B cells, NK cells, macrophages, eosinophils
4–1BBL (TNFSF9)	APCs (DCs, macrophages and B cells), mast cells	4–1BB (TNFRSF9), CD137, ILA	T, NK and mast cells, neutrophils
TRAIL (TNFSF10), Apo2L	NK and T cells, DCs	TRAILR1 (TNFRSF10A), DR4, Apo2	Most normal and transformed cells
		TRAILR2 (TNFRSF10B), DR5
		TRAILR3 (TNFRSF10C), DcR1
		TRAILR4 (TNFRSF10D), DcR2
RANKL (TNFSF11), TRANCE, OPGL, ODF	T cells, thymus, lymph nodes	RANK (TNFRSF11A), TRANCER	Osteoclasts, osteoblasts, and activated T cells
		OPG (TNFRSF11B), OCIF	Bone marrow stromal cells, B cells, DCs
TWEAK (TNFSF12), Apo3L	Monocytes, macrophages, DCs, NK cells	Fn14 (TNFRSF12A), TWEAKR	Endothelial cells and fibroblasts, tissue progenitor cells
	T and B cells
APRIL (TNFSF13), TALL-2, TRDL-1	Macrophages, lymphoid cells and tumor cells	BCMA (TNFRSF13A/17)	B cells, PBLs, spleen, thymus, lymph nodes, liver, adrenals
		TACI (TNFRSF13B)	B cells, activated T cells, PBLs, spleen, thymus, small intestine
BAFF (TNFSF13B), BLYS, THANK	T cells, monocytes, macrophages, DCs	TACI (TNFRSF13B)	B cells, resting T cells, PBLs, spleen, lymph nodes
		BAFFR (TNFRSF13C)
		BCMA (TNFRSF17)
LIGHT (TNFSF14), HVEML, LT-γ	T cells, granulocytes, monocytes, DCs	LIGHTR (TNFRSF14), HVEM	T and B cells, monocytes, and lymphoid cells
		LT-βR	Nonlymphoid hematopoietic and stromal cells
TL1A (TNFSF15), VEGI	Endothelial cells	DR3 (TNFRSF25)	NK cells, CD4+ and CD8+ cells
	APCs	DcR3	Activated T cells
GITRL (TNFSF18)	HUVECs	GITR (TNFRSF18), AITR	CD4+ CD25+ T cells
EDA-A1	Skin	EDAR	Ectodermal derivative
EDA-A2	Skin	XEDAR (TNFRSF27)	Ectodermal derivative, embryonic hair follicles
NI		TROY (TNFRSF19), TAJ	Embryo skin, epithelium, hair follicles, brain
NI		RELT (TNFRSF19L)	Lymphoid and hematopoietic tissues
Amyloid polypeptide (APP) (not a TNFSF member)		DR6 (TNFRSF21)	Differentiating neurons, T cells
NI		NGFR (TNFRSF16), CD271	Neuronal axons, Schwann cells, perineural cells

Members of the TNF/TNFR superfamilies ]]>