Szelenyi et al. demonstrate that adult brain XCI is systematically biased toward maternal X-active cells, which is sufficient for disease penetrance of the X-linked Fmr1-KO allele. Furthermore, local XCI mosaicism distinguishes phenotypic outcomes of individuals based on mutant X-active cells populating […]
Environmentally dependent and independent control of 3D cell shape
Using high-throughput light-sheet microscopy, Dent et al. study 3D cancer cell morphogenesis. Environmental cues modulate the opposing roles of non-muscle myosin II (myosin) and microtubules, with varied impacts on RhoGEFs FARP1 and TIAM2. The study underscores the critical interplay between cytoskeletal […]
Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling
Fields et al. demonstrate the viability of targeting a shared cytokine receptor for comprehensive signaling blockade of all associated cytokines. CAN10 and 3G5, two anti-IL-1RAcP antibodies, target distinct epitopes on this shared receptor and potently block IL-1α, IL-1β, IL-33, IL-36α, IL-36β, […]
LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion
Terao et al. demonstrated how dysregulated cholesterol metabolism drives macrophage senescence and the development of subretinal drusenoid deposits in mice. LXR/CD38 signaling activated by cholesterol reduces NAD+ availability and promotes macrophage senescence. Senolytic agents targeting NAD+ decline and senescent macrophages are […]
Why Your Doc Says “No Evidence” for Vitamin Supplements…
We’ve all heard the mantra: “Eat a balanced diet and you’ll be healthy.” It sounds simple, right? But the reality is, with our modern, often depleted food sources, achieving an “optimal” intake of all the nutrients our bodies need through […]
Coenzyme Q10 (CoQ10) – Can it Fight Cancer?
Cancer is a complex disease, and researchers are constantly searching for new and improved methods for prevention and treatment. Antioxidants have gained interest for their potential role in combating cancer, and Coenzyme Q10 (CoQ10) is one such antioxidant that has […]
Emerging Cancer Treatments Based on New Theory of Cancer
It’s been over 50 years since Nixon declared a War on Cancer, predicting to end cancer by 1978. Nixon’s declaration of “war” empowered congress to budget billions of dollars for research.
What have we gotten for the hundreds of billions of dollars and five decades of research?