NCI Director Kimryn Rathmell evoked Taylor Swift to present her vision of the 360 era for cancer research.
The post NCI Director Introduces New Era of Cancer Research appeared first on American Association for Cancer Research (AACR).
Brain cancer in children is notoriously hard to treat – a new mRNA cancer vaccine triggers an attack from within Health – The Conversation
Cancer vaccines have gained much interest among scientists but face a number of hurdles. A new mRNA vaccine for glioma offers a step forward in training the immune system to fight cancer.
Electrical Grounding: Investigating the Effects of Exogenous Electricity on Endogenous Bioelectrical States
In the late 1950’s: (1) autoimmune diseases (including cancer) began rising rapidly and (2) mass manufacturing of rubber-soled shoes began. Are the two related?
Hydrogen Therapy: A Promising New Treatment for Lung Cancer
Hydrogen inhalation therapy – an emerging therapy for lung cancer, appears to be both safe and effective.
A fitness landscape instability governs the morphological diversity of tip-growing cells
Ohairwe et al. demonstrate that an intrinsic mechanical instability in the convergent mechanism of “inflationary” cell growth shared by diverse tip-growing cells leads to a bifurcation (branching) of their fitness landscape. This bifurcation strictly constrains natural tip-growing cell shapes.
The soil microbiome modulates the sorghum root metabolome and cellular traits with a concomitant reduction of Striga infection
The soil microbiome protects sorghum, and likely other crops, from infection with the root parasite Striga hermonthica. Kawa et al. show that soil-borne bacteria modify sorghum root development and root exudate content, likely preventing Striga from penetrating sorghum. This study provides […]
Genomic deletions explain the generation of alternative BRAF isoforms conferring resistance to MAPK inhibitors in melanoma
Aya et al. show that the production of alternative BRAF mRNA isoforms (altBRAFs), associated with resistance to BRAF inhibitors in melanoma, is caused by genomic deletions rather than by alternative splicing, as previously thought. They also find that altBRAFs are present […]
The nociceptive activity of peripheral sensory neurons is modulated by the neuronal membrane proteasome
Proteasomes are critical for sensory neuron function. Villalón Landeros et al. uncover a specialized proteasome in somatosensory neurons called the neuronal membrane proteasome (NMP). The NMP mediates crosstalk between somatosensory neurons to modulate sensitivity to stimulation. Inhibition of the NMP reduces […]
Distributed X chromosome inactivation in brain circuitry is associated with X-linked disease penetrance of behavior
Szelenyi et al. demonstrate that adult brain XCI is systematically biased toward maternal X-active cells, which is sufficient for disease penetrance of the X-linked Fmr1-KO allele. Furthermore, local XCI mosaicism distinguishes phenotypic outcomes of individuals based on mutant X-active cells populating […]
Environmentally dependent and independent control of 3D cell shape
Using high-throughput light-sheet microscopy, Dent et al. study 3D cancer cell morphogenesis. Environmental cues modulate the opposing roles of non-muscle myosin II (myosin) and microtubules, with varied impacts on RhoGEFs FARP1 and TIAM2. The study underscores the critical interplay between cytoskeletal […]