Fields et al. demonstrate the viability of targeting a shared cytokine receptor for comprehensive signaling blockade of all associated cytokines. CAN10 and 3G5, two anti-IL-1RAcP antibodies, target distinct epitopes on this shared receptor and potently block IL-1α, IL-1β, IL-33, IL-36α, IL-36β, […]
LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion
Terao et al. demonstrated how dysregulated cholesterol metabolism drives macrophage senescence and the development of subretinal drusenoid deposits in mice. LXR/CD38 signaling activated by cholesterol reduces NAD+ availability and promotes macrophage senescence. Senolytic agents targeting NAD+ decline and senescent macrophages are […]
Why Your Doc Says “No Evidence” for Vitamin Supplements…
We’ve all heard the mantra: “Eat a balanced diet and you’ll be healthy.” It sounds simple, right? But the reality is, with our modern, often depleted food sources, achieving an “optimal” intake of all the nutrients our bodies need through […]
Coenzyme Q10 (CoQ10) – Can it Fight Cancer?
Cancer is a complex disease, and researchers are constantly searching for new and improved methods for prevention and treatment. Antioxidants have gained interest for their potential role in combating cancer, and Coenzyme Q10 (CoQ10) is one such antioxidant that has […]
Emerging Cancer Treatments Based on New Theory of Cancer
It’s been over 50 years since Nixon declared a War on Cancer, predicting to end cancer by 1978. Nixon’s declaration of “war” empowered congress to budget billions of dollars for research.
What have we gotten for the hundreds of billions of dollars and five decades of research?